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221 Main - Restaurant & Cocktail House

Our Story

Welcome to 221 Main - Restaurant & Cocktail House, an award-winning steakhouse located in the heart of St. Joseph, Michigan. Since 2012, we have been dedicated to providing an unforgettable dining experience with a menu that celebrates exceptional flavor and quality. We pride ourselves on offering a diverse range of dishes, all crafted from the finest ingredients.

At 221 Main, we specialize in steaks. Our offerings include classic cuts like ribeye and filet mignon, available daily to ensure every visit feels like a special occasion. For those seeking something unique, our signature Surf-n-Turf and BC Ribeye, seasoned to perfection, are standout dishes that elevate your dining experience. Each bite reflects our commitment to quality and flavor, making our steaks a memorable part of your visit.

Seafood enthusiasts will appreciate our fresh Atlantic Salmon and Perch, which capture the essence of coastal cuisine. Other popular dishes include Chicken Marsala, creamy Mac & Cheese, and our flavorful Seafood Pasta—each one crafted with care to satisfy every palate. Whether it’s a casual dinner or a special celebration, 221 Main offers a menu sure to delight.

Our vibrant bar scene is the perfect complement to our food. Enjoy hand-crafted cocktails expertly mixed to enhance your meal, or choose from a selection of local craft beers and global wines. With something for every taste, we ensure that your drink experience is as enjoyable as your meal.

221 Main is also an ideal venue for private events, offering event space rentals for gatherings of all sizes. Our private dining options offer a personalized touch for your special occasions. We also offer convenient takeout services, so you can enjoy our cuisine wherever you are.

What truly sets 221 Main apart is our commitment to hospitality. From the moment you walk in, our attentive staff ensures that your dining experience exceeds expectations. Join us at 221 Main - Restaurant & Cocktail House and discover why we’ve become a beloved dining destination in St. Joseph!

What We Offer

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Testimonials

On 8/17/2025 Janice Dawson had this to say:
The Copper Pot is our favorite breakfast place. The staff is also very friendly ❤️

On 8/11/2025 Dawn Barry had this to say:
This was our first visit at 221 Main. Best experience for sure. The food was amazing. We had appetizers, salads and our entrees were delicious. I had the BC Ribeye. The bleu cheese butter on the steak was a perfect touch, the mushroom and mashed potatoes were spectacular. My husband ordered the salmon piccata-cooked to perfection and the piccata sauce was smooth creamy and delicious. Our server was Jesica and she was attentive, not pushy to get us to order with it being our first time, she gave us time to look everything over. Our food came out perfect timing. I don't like a food/plate back up because everything comes out so quickly. She gave us the best service. All the servers, while very busy, every time they passed our table they had a smile on their faces. The owner checked on us several times to make sure all was well. When we left, he was outside taking care of the outside tables and stopped, even though he was busy to chat for a few minutes. Overall, great experience and will be frequent diners. Thank you Jesica for a wonderful dining experience.

On 8/11/2025 Mary RV had this to say:
Had a great dinner; lake perch was delicately breaded with a light lemon sauce that made it that much more delicious..... had the apple bread pudding for dessert and can still taste the yummy flavors

On 8/10/2025 Fernanda Martinez Garza had this to say:
The best parmesan encrusted whitefish. My favorite and my go to

On 8/9/2025 Josh Smith had this to say:
Ate here last night; amazing food and service! Server was great and had great recommendations and the bartender made outstanding drinks. Best food we've had in a while, even the kids meals were good. Owner was super friendly and made sure everything was great, excellent atmosphere and experience. We'll definitely be back.

Contact Us

221 Main - Restaurant & Cocktail House
221 Main St St joseph, MI 49085
Phone: (269) 982-4000
Email: 221reservations@gmail.com

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Payment Types Accepted

American Express, Android Pay, Apple Pay, Cash, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Wednesday: 4:30 PM - 8:30 PM
Thursday: 4:30 PM - 8:30 PM
Friday: 4:30 PM - 9:00 PM
Saturday: 4:30 PM - 9:00 PM
Sunday: 4:30 PM - 8:30 PM

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