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221 Main - Restaurant & Cocktail House

Our Story

Welcome to 221 Main - Restaurant & Cocktail House, an award-winning steakhouse located in the heart of St. Joseph, Michigan. Since 2012, we have been dedicated to providing an unforgettable dining experience with a menu that celebrates exceptional flavor and quality. We pride ourselves on offering a diverse range of dishes, all crafted from the finest ingredients.

At 221 Main, we specialize in steaks. Our offerings include classic cuts like ribeye and filet mignon, available daily to ensure every visit feels like a special occasion. For those seeking something unique, our signature Surf-n-Turf and BC Ribeye, seasoned to perfection, are standout dishes that elevate your dining experience. Each bite reflects our commitment to quality and flavor, making our steaks a memorable part of your visit.

Seafood enthusiasts will appreciate our fresh Atlantic Salmon and Perch, which capture the essence of coastal cuisine. Other popular dishes include Chicken Marsala, creamy Mac & Cheese, and our flavorful Seafood Pasta—each one crafted with care to satisfy every palate. Whether it’s a casual dinner or a special celebration, 221 Main offers a menu sure to delight.

Our vibrant bar scene is the perfect complement to our food. Enjoy hand-crafted cocktails expertly mixed to enhance your meal, or choose from a selection of local craft beers and global wines. With something for every taste, we ensure that your drink experience is as enjoyable as your meal.

221 Main is also an ideal venue for private events, offering event space rentals for gatherings of all sizes. Our private dining options offer a personalized touch for your special occasions. We also offer convenient takeout services, so you can enjoy our cuisine wherever you are.

What truly sets 221 Main apart is our commitment to hospitality. From the moment you walk in, our attentive staff ensures that your dining experience exceeds expectations. Join us at 221 Main - Restaurant & Cocktail House and discover why we’ve become a beloved dining destination in St. Joseph!

What We Offer

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Testimonials

On 2/15/2025 Taylor Michael had this to say:
Absolutely amazing food! The owner is so nice and very hands on. The staff is fantastic and the restaurant is so cozy. Highly recommend!! The lobster was the best I’ve ever had.

On 2/14/2025 Heather Faanunu had this to say:
Boy are we glad that we chose this restaurant to celebrate Valentine’s Day! Everything was cooked to perfection. (I rarely post reviews so, you should know it’s GOOD when this Momma of five takes the time to write one for my fellow foodies;) For an appetizer, we had the bacon honey brussel sprouts that were the best I’ve had (and I’ve tried them all at restaurants in the St Joseph area)- a perfect combo of savory and hint of sweet. The Caesar salad was generously sized, crisp, and delicious! For the entrée, I ordered the Surf and Turf and my husband ordered the Garlic Ribeye. The filet mignon was so tender and I enjoyed the best lobster tail I ever had- cooked ever so perfectly to maintain its sweetness and meat delicately firm (I love good seafood!) The mashed potatoes, sauce, and asparagus were also very good and a perfect pairing. My husband highly enjoyed his Garlic Ribeye- it was FULL of flavor and melted in your mouth. Our server Crystal was WONDERFUL keeping our glasses full through the night, checking in often to make sure we were doing well, and informing us of the timing of things. The owner stopped by to check in with us as well which was a wonderful surprise. Lastly, a HUGE shout out to chef Chris who was flying solo tonight and cooked everything PERFECTLY!!! Amazing job! If you are looking for an amazing restaurant with food that you will enjoy to the last bite and crave the moment you get home, this is the place for you!

On 2/12/2025 Outdoor Alchemy had this to say:
Everything was perfect. Absolutely stunning decor, staff was amazing and knowledgeable. Highly recommend.

On 2/12/2025 Kina had this to say:
Eggs Benedict was amazing

On 2/8/2025 Suzanne Kubvaruno had this to say:
Dined here on 2/7/25 and had the best experience! The food, the waitstaff and the atmosphere were all wonderful! Even the manager took time out of her busy night to check on our party, very impressive! Please check this place out, you won’t be disappointed!

Contact Us

221 Main - Restaurant & Cocktail House
221 Main St St joseph, MI 49085
Phone: (269) 982-4000
Email: 221reservations@gmail.com

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Payment Types Accepted

American Express, Android Pay, Apple Pay, Cash, Debit Cards, Discover, MasterCard, Visa

Our Hours

Holiday Hours May Vary. Please Call For Details.

Thursday: 5:00 PM - 9:00 PM
Friday: 5:00 PM - 9:00 PM
Saturday: 5:00 PM - 9:00 PM
Sunday: 5:00 PM - 9:00 PM

News

Join us for an unforgettable evening at 221 Main Restaurant & Cocktail House! 🍽️🥃 We're hosting a 5-Course Whiskey Dinner on Thursday, April 10th at 6 PM. Indulge in exquisite dishes paired with fine whiskeys for just $125 per person (tax and gratuity not included). With only 50 seats available, don't wait—call us today to secure your spot! To view the menu, select "5-Course Whiskey Dinner" under our menu options to see what awaits. Cheers to a night of culinary delight!

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Dinner
Gluten-Free
Dessert
Wine
Whiskey
Cocktail
BARtini
5-Course Whiskey Dinner

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