Since 2012, 221 Main Restaurant and Cocktail House has set the standard for elevated dining in Saint Joseph, Michigan. Our award-winning steakhouse is known for hand-selected cuts, fresh seafood and signature dishes—each one prepared entirely from scratch, from sauces to finishing touches. Behind the bar, we proudly boast the largest whiskey collection in Southwest Michigan with more than 335 bottles to explore, alongside handcrafted cocktails, a curated global wine list and local craft beers. Whether you’re joining us for an intimate dinner, a celebratory gathering or simply the pleasure of exceptional food and drink in a refined, swanky setting, 221 Main offers an experience where every detail is designed to impress.