Welcome to 221 Main - Restaurant & Cocktail House an award-winning steakhouse in the heart of St. Joseph, MI. Since 2012, we have been delighting diners with our delicious steaks, seafood dishes, burgers, and an extensive selection of wines, craft cocktails, and draft beers. Beyond our exceptional menu, we also offer event space rentals, catering services, private dining options, and convenient takeout for those craving our delectable dishes at home. Come experience the perfect blend of culinary excellence and warm hospitality at 221 Main - where every meal is an unforgettable experience. Stop by today!